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KMID : 0376219800170020453
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Chonnam Medical Journal
1980 Volume.17 No. 2 p.453 ~ p.461
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Histochemical and Enzyme Histochemical Studies on Mucinous Adenocarcinoma of Stomach
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Abstract
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The authors studied histochemically and enzyme histochemically the neoplastic cells in 30 cases of mucinous adenocarcinoma of stomach and also studied 8 cases of chronic atrophic gastritis with intestinal metaplasia and 5 cases of normal gastric mucosa.
The mucosubstances in all of these specimens were stained with PAS, alcian blue(pH 1.0 and 2.5), and alcian blue-PAS. Enzyme activities were detected by stains for acid phosphatase, alkaline phosphatase, and succinic dehydrogenase.
The results obtained were as follows.
1. Mucosubstances in normal gastric mucosa were neutral mucin.
2. Histochemical property of mucosubstances in chronic atrophic gastritis with intestinal metaplasia showed variability, but most of them were acid mucin.
3. Histochemical property of mucosubstances in mucinous adenocarcinoma cells showed marked variability, but most of tumor cells contained acid and neutral mucins.
4. The enzyme activity in neoplastic cells showed marked variability but the average activity of all enzymes studied was inferior to that found in intestinal metaplasia, and greater than or equal to that exhibited by the cytoplasm, of the normal mucosal cells.
These observations permit the conclusion that mucinous adenocarcinoma of stomach is not always followed by intestinal metaplasia of gastric glands.
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